$225.00 – $795.00
Product name: Methadone
Generic Name: Methadone
Brand Names: (Methadose, Diskets, Dolophine)
Dosage Strength(s): 5 MG, 10 MG
Quantity: 100 – 450 Tablets
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Methadone is part of a category called opioids. It was created by German doctors during World War II. When it arrived in the United States, it was used to treat people with extreme pain. Today, your doctor may use it as part of your treatment for an addiction to heroin or narcotic painkillers.
It works a lot like morphine does. You can take it as a tablet, a powder, or a liquid. It must be prescribed by a doctor. People who take it illegally often inject it, which exposes them to diseases like HIV.
Even though it’s safer than some other narcotics, your doctor should keep a close watch on you while you take methadone. Taking it can lead to addiction or abuse.
Methadone changes the way your brain and nervous system respond to pain so that you feel relief. Its effects are slower than those of other strong painkillers like morphine. It blocks the high you get from drugs like codeine, heroin, hydrocodone, morphine, and oxycodone.
Your doctor may prescribe methadone if you’re in a lot of pain from an injury, surgery, or chronic illness.
It can also help if you’re in treatment for addiction to other opioids. It can give a similar feeling and prevent withdrawal symptoms. You may hear this called replacement therapy. Methadone replaces the opioids in your system with milder effects.
For detoxification treatment of opioid addiction (heroin or other morphine-like drugs).
For maintenance treatment of opioid addiction (heroin or other morphine-like drugs), in conjunction with appropriate social and medical services.
Methadone differs from many other opioid agonists in several important ways. Methadone’s pharmacokinetic properties, coupled with high interpatient variability in its absorption, metabolism, and relative analgesic potency, necessitate a cautious and highly individualized approach to prescribing. Particular vigilance is necessary during treatment initiation, during conversion from one opioid to another, and during dos e titration.
While methadone’s duration of analgesic action (typically 4 to 8 hours) in the setting of single-dose studies approximates that of morphine, methadone’s plasma elimination half-life is substantially longer than that of morphine (typically 8 to 59 hours vs. 1 to 5 hours). Methadone’s peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects. Also, with repeated dosing, methadone may be retained in the liver and then slowly released, prolonging the duration of action despite low plasma concentrations. For these reasons, steady-state plasma concentrations, and full analgesic effects, are usually not attained until 3 to 5 days of dosing. Additionally, incomplete cross-tolerance between mu-opioid agonists makes determination of dosing during opioid conversion complex.
The complexities associated with methadone dosing can contribute to cases of iatrogenic overdose, particularly during treatment initiation and dose titration. A high degree of “opioid tolerance” does not eliminate the possibility of methadone overdose, iatrogenic or otherwise. Deaths have been reported during conversion to methadone from chronic, high-dose treatment with other opioid agonists and during initiation of methadone treatment of addiction in subjects previously abusing high doses of other agonists .
Detoxification And Maintenance Treatment of Opiate Dependence
For detoxification and maintenance of opiate dependence methadone should be administered in accordance with the treatment standards cited in 42 CFR Section 8.12, including limitations on unsupervised administration.
The initial methadone dose should be administered, under supervision, when there are no signs of sedation or intoxication, and the patient shows symptoms of withdrawal. Initially, a single dose of 20 to 30 mg of methadone will often be sufficient to suppress withdrawal symptoms. The initial dose should not exceed 30 mg. If same-day dosing adjustments are to be made, the patient should be asked to wait 2 to 4 hours for further evaluation, when peak levels have been reached. An additional 5 to 10 mg of methadone may be provided if withdrawal symptoms have not been suppressed or if symptoms reappear. The total daily dose of methadone on the first day of treatment should not ordinarily exceed 40 mg. Dose adjustments should be made over the first week of treatment based on control of withdrawal symptoms at the time of expected peak activity (e.g., 2 to 4 hours after dosing). Dose adjustment should be cautious; deaths have occurred in early treatment due to the cumulative effects of the first several days’ dosing. Patients should be reminded that the dose will “hold” for a longer period of time as tissue stores of methadone accumulate.
Initial doses should be lower for patients whose tolerance is expected to be low at treatment entry. Loss of tolerance should be considered in any patient who has not taken opioids for more than 5 days. Initial doses should not be determined by previous treatment episodes or dollars spent per day on illicit drug use.
For Short-Term Detoxification
For patients preferring a brief course of stabilization followed by a period of medically supervised withdrawal, it is generally recommended that the patient be titrated to a total daily dose of about 40 mg in divided doses to achieve an adequate stabilizing level. Stabilization can be continued for 2 to 3 days, after which the dose of methadone should be gradually decreased. The rate at which methadone is decreased should be determined separately for each patient. The dose of methadone can be decreased on a daily basis or at 2-day intervals, but the amount of intake should remain sufficient to keep withdrawal symptoms at a tolerable level. In hospitalized patients, a daily reduction of 20% of the total daily dose may be tolerated. In ambulatory patients, a somewhat slower schedule may be needed.
For Maintenance Treatment
Patients in maintenance treatment should be titrated to a dose at which opioid symptoms are prevented for 24 hours, drug hunger or craving is reduced, the euphoric effects of self-administered opioids are blocked or attenuated, and the patient is tolerant to the sedative effects of methadone. Most commonly, clinical stability is achieved at doses between 80 to 120 mg/day.
For Medically Supervised Withdrawal After A Period Of Maintenance Treatment
There is considerable variability in the appropriate rate of methadone taper in patients choosing medically supervised withdrawal from methadone treatment. It is generally suggested that dose reductions should be less than 10% of the established tolerance or maintenance dose, and that 10 to 14- day intervals should elapse between dose reductions. Patients should be apprised of the high risk of relapse to illicit drug use associated with discontinuation of methadone maintenance treatment.
Overdose symptoms can include:
Slow heart rate
Cold, clammy skin
METHADONE SIDE EFFECTS
While there’s no set amount of time you’ll take methadone to treat an addiction, experts say it should be at least a year, and maybe more than that. The doctor will carefully track your body’s response to it and adjust your treatment. When it’s time to stop taking it, he’ll help you stop slowly to prevent withdrawal.
With short-term use, you may notice:
Nausea or vomiting
Some side effects are more serious. Call the doctor if you:
Have trouble breathing or can only take shallow breaths
Feel lightheaded or faint
Get hives or a rash
Have swollen lips, tongue, throat, or face
Have chest pain or a rapid heartbeat
Have hallucinations or feel confused
If you use the drug for a long time, it might lead to lung and breathing problems. It can also change a woman’s menstrual cycle. If you get pregnant, talk to your doctor about changing your dose. It can cause complications.
What Are the Risks?
Some people shouldn’t take methadone. Tell your doctor if you have:
A heart rhythm disorder
An electrolyte imbalance
Breathing problems or lung disease
A history of head injury, brain tumor, or seizures
Liver or kidney disease
Gallbladder, pancreas, or thyroid problems
A condition for which you take sedatives
Drugs than can affect methadone include:
Drugs that make you sleepy or slow your breathing
Drugs that change your serotonin level
You can become dependent on it. Your brain may begin to rely on the pain relief it brings.
Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient.
Inspire Health Pharmaceuticals does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.
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