$195.00 – $900.00
Product name: Xanax XR
Generic Name: (alprazolam) Extended-Release Tablets
Drug Class: Benzodiazepines
Steroid cycle: Antidepressants
Pregnancy Category: D – Positive evidence of risk
CSA Schedule: 4 – Some potential for abuse
Labeler / Supplier: Pfizer U.S. Pharmaceuticals Group
Dosage Strength(s): 0.5 mg, 1 mg, 2 mg, 3 mg
Quantity: 100 – 750 Tablets
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XANAX XR Tablets contain alprazolam which is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds.
Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH.
Each XANAX XR extended-release tablet, for oral administration, contains 0.5 mg, 1 mg, 2 mg, or 3 mg of alprazolam. The inactive ingredients are lactose, magnesium stearate, colloidal silicon dioxide, and hypromellose. In addition, the 1 mg and 3 mg tablets contain D & C yellow No. 10 and the 2 mg and 3 mg tablets contain FD&C blue No. 2.
XANAX XR Tablets are indicated for the treatment of panic disorder, with or without agoraphobia.
This claim is supported on the basis of two positive studies with XANAX XR conducted in patients whose diagnoses corresponded closely to the DSM-III-R/IV criteria for panic disorder.
Panic disorder (DSM-IV) is characterized by recurrent unexpected panic attacks, ie, a discrete period of intense fear or discomfort in which four (or more) of the following symptoms develop abruptly and reach a peak within 10 minutes:
- palpitations, pounding heart, or accelerated heart rate;
- trembling or shaking;
- sensations of shortness of breath or smothering;
- feeling of choking;
- chest pain or discomfort;
- nausea or abdominal distress;
- feeling dizzy, unsteady, lightheaded, or faint;
- derealization (feelings of unreality) or depersonalization (being detached from oneself);
- fear of losing control;
- fear of dying;
- paresthesias (numbness or tingling sensations);
- chills or hot flushes.
The longer-term efficacy of XANAX XR has not been systematically evaluated. Thus, the physician who elects to use this drug for periods longer than 8 weeks should periodically reassess the usefulness of the drug for the individual patient.
Also among the components of the drug are less active substances, which act as support. IT elements, such as lactose, magnesium stearate, colloidal silicon dioxide.
The main feature of the preparation is considered its light absorption by the human body.
Xanax XR tablets are indicated for the treatment of panic disorder with or without agoraphobia.
Xanax XR long-term efficacy has not been systematically evaluated. Therefore, the physician who elects to use this medicine for longer than 8 weeks should periodically reassess the usefulness of the drug for the individual patient.
This medicine has very good qualities for the treatment of disorders of sleep and relaxation functions of the body, the treatment of negative phenomena such as the irrational fear, insomnia, constant severe anxiety.
Studies have shown that the drug in doses lower than peers, can significantly improve sleep quality in patients, reducing the number of nighttime awakenings, which helps get rid of the feelings of fear, anxiety and aggression.
In the same patients they showed a significant decrease in time to fall asleep, and the length of time healthy sleep.
Pay attention to the fact that the only real drug is able to exert such effect. A large number of counterfeit materials, not only take final effect desired positive, but also cause disease and many other problems in patients. Therefore, one has only to take a true original drug, and never for any purpose to acquire and make all kinds of similar preparations, substitutes and other products.
Also, do not forget, and that compliance with all recommendations of the physician and the minimum dose should be the main rule. Failure to follow these rules can lead to serious consequences, among which are as addiction, the functions of sleep disorders, mental stimulation, violation of human internal organs functioning central nervous system disorder, etc.
XANAX XR Tablets may be administered once daily, preferably in the morning. The tablets should be taken intact; they should not be chewed, crushed, or broken.
The suggested total daily dose ranges between 3 to 6 mg/day. Dosage should be individualized for maximum beneficial effect. While the suggested total daily dosages given will meet the needs of most patients, there will be some patients who require doses greater than 6 mg/day. In such cases, dosage should be increased cautiously to avoid adverse effects.
Dosing In Special Populations
In elderly patients, in patients with advanced liver disease, or in patients with debilitating disease, the usual starting dose of XANAX XR is 0.5 mg once daily. This may be gradually increased if needed and tolerated.The elderly may be especially sensitive to the effects of benzodiazepines.
Treatment with XANAX XR may be initiated with a dose of 0.5 mg to 1 mg once daily. Depending on the response, the dose may be increased at intervals of 3 to 4 days in increments of no more than 1 mg/day. Slower titration to the dose levels may be advisable to allow full expression of the pharmacodynamic effect of XANAX XR.
Generally, therapy should be initiated at a low dose to minimize the risk of adverse responses in patients especially sensitive to the drug. Dose should be advanced until an acceptable 21 therapeutic response (ie, a substantial reduction in or total elimination of panic attacks) is achieved, intolerance occurs, or the maximum recommended dose is attained.
In controlled trials conducted to establish the efficacy of XANAX XR Tablets in panic disorder, doses in the range of 1 to 10 mg/day were used. Most patients showed efficacy in the dose range of 3 to 6 mg/day. Occasional patients required as much as 10 mg/day to achieve a successful response.
The necessary duration of treatment for panic disorder patients responding to XANAX XR is unknown. However, periodic reassessment is advised. After a period of extended freedom from attacks, a carefully supervised tapered discontinuation may be attempted, but there is evidence that this may often be difficult to accomplish without recurrence of symptoms and/or the manifestation of withdrawal phenomena.
Because of the danger of withdrawal, abrupt discontinuation of treatment should be avoided.
In all patients, dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. Although there are no systematically collected data to support a specific discontinuation schedule, it is suggested that the daily dosage be decreased by no more than 0.5 mg every three days. Some patients may require an even slower dosage reduction.
In any case, reduction of dose must be undertaken under close supervision and must be gradual. If significant withdrawal symptoms develop, the previous dosing schedule should be reinstituted and, only after stabilization, should a less rapid schedule of discontinuation be attempted. In a controlled postmarketing discontinuation study of panic disorder patients which compared this recommended taper schedule with a slower taper schedule, no difference was observed between the groups in the proportion of patients who tapered to zero dose; however, the slower schedule was associated with a reduction in symptoms associated with a withdrawal syndrome. It is suggested that the dose be reduced by no more than 0.5 mg every three days, with the understanding that some patients may benefit from an even more gradual discontinuation. Some patients may prove resistant to all discontinuation regimens.
Switch From XANAX (Immediate-Release) Tablets To XANAX XR (Extended-Release) Tablets
Patients who are currently being treated with divided doses of XANAX (immediate-release) Tablets, for example 3 to 4 times a day, may be switched to XANAX XR Tablets at the same total daily dose taken once daily. If the therapeutic response after switching is inadequate, the dosage may be titrated as outlined above.
XANAX SIDE EFFECTS
Xanax XR tablets are contraindicated in patients with known hypersensitivity to this drug or other benzodiazepines. Xanax XR can be used in patients with open-angle glaucoma who receive proper treatment, but is contraindicated in patients with acute narrow-angle glaucoma.
Xanax XR is contraindicated with ketoconazole and itraconazole, since these medications significantly reduce oxidative metabolism mediated by cytochrome P450 3A (CYP3A).
Often, the side effects patients may experience symptoms such as nausea, headache, muscle weakness, general apathy and loss of interest in the outside world.
In some cases, there may be an increased aggression against people and animals, loss of libido and potency.
To prevent various kinds of side effects observe the correct dosage of the drug and to avoid a sharp increase and decrease.
In addition, the patient must be under constant medical supervision, which in the case of a change in their situation could take certain steps.
Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient.
Inspire Health Pharmaceuticals does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.
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